Phenergan is used for relieving allergy symptoms, including hives or runny nose. It is used to prevent and control nausea and vomiting during and after surgery. It is also used as a sedative or sleep aid.
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Phenergan oral vs suppository ) compared with placebo. The primary efficacy endpoint was proportion of patients achieving a 5-month adverse event (AE) resolution. Secondary efficacy endpoints were the proportion of patients achieving a reduction in the risk phenergan 25 mg oral of major and depression symptoms, the proportion of patients achieving a reduction in the risk of suicidal thinking or behavior, and the proportion of patients achieving a reduction in the risk of hypomanic or episodes. The primary safety endpoint was proportion of patients who did not experience the prespecified AEs. Secondary safety endpoints were the likelihood of discontinuing therapy, incidence discontinuation due to of the trial drug due to AEs, the number and severity of AE compared with placebo, and the numbers severity of discontinuation due to different AEs. If a study received positive signal, the trial was stopped as rapid exploratory treatment was undertaken. Results are expressed as the mean ± SE (inter-quartile range). Statistical analysis was performed without use of randomization order or subgroup analysis. All reported P values are two-sided in the original paper. Results are not reported if the treatment group was not defined at randomization. In the post hoc analyses, each group's mean difference was assessed across the different primary efficacy parameters in order to calculate a sample size at which statistical significance could be established. For data with significant differences among the groups, a Bonferonni correction was used. P values less than 0.05 were considered statistically significant. Results Characteristics of the Study Population Thirty-two participants (mean (SD) age, 51.7 (8.7) years) were enrolled. The treatment groups well balanced in age and sex composition: eight (58.3%; 17 women, 43 men) of eight participants were men and women. A total of 24 subjects were taking a single dose of daily formulation emetrol versus 17 participants taking either placebo or suppository. A total of 528 subjects (mean (SD) age, 47.3 (8.7) years) completed the study during which time all subjects (1333 subjects) had at least two follow-ups with all baseline assessments completed. Patients randomized to emetrol had penalty for drug trafficking in canada a mean (SD) age of 49.1 (7.7) years with a range of 18.5-90.3 years and 1.3 percent had a past history of major depression (one or more episodes) compared with 2.1 percent of placebo- or suppository-treated patients. The EMA was primary efficacy endpoint with all eight subjects receiving emetrol achieving complete response at study end. Three subjects were discontinued for a reason other than complete response. Of the five subjects who experienced an adverse event, the most frequently reported (and reason for discontinuation) was nausea (n = 5; 2.2 percent), followed by insomnia (n = 1; 0.8 percent), headache (n = 1; 0.8 percent), fever (n = 1; 0.8 percent), back or neck pain (n = 1; 0.8 percent), and increased appetite (n = 1). Two completed suicide; neither was under the influence of medication. Table 1 summarizes baseline demographic information of the study groups.
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